All enzymes of TCA cycle are located in the mitochondrial matrix except one which is located in inner mitochondrial membranes in eukaryotes and in cytosol in prokaryotes. This enzyme is

Options

(a) isocitrate dehydrogenase
(b) malate dehydrogenase
(c) succinate dehydrogenase
(d) lactate dehydrogenase.

Correct Answer:

succinate dehydrogenase

Explanation:

Succinate:ubiquinone oxidoreductase, also known in mitochondria as Complex II, provides a link between the citric acid cycle and the membrane-bound electron transport system. The membrane extrinsic, water-soluble domain, known as succinate dehydrogenase (SDH), contains the fumarate/succinate active site with a covalently bound FAD group and three iron-sulfur clusters[2Fe-2S]² + /1+, [4Fe-4S]² +/1+, and [3Fe-4S]¹ +/0. The enzyme catalyzes the interconversion of fumarate and succinate, and is closely related to fumarate reductase.